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MRT68921

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品牌: MedChemExpress
单价: 面议
起订:
供货总量:
发货期限: 自买家付款之日起 3 天内发货
所在地: 中国 上海
有效期至: 长期有效
最后更新: 2017-12-11 12:21
浏览次数: 93
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公司基本资料信息
 
 
产品详细说明
MRT68921是<b>ULK1</b>和<b>ULK2</b>最有效的抑制剂,<b>IC<sub>50</sub></b>值分别为2.9 nM和1.1 nM.
<BR><a href="https://www.medchemexpress.cn/SKF-96365-hydrochloride.html">SKF-96365 (hydrochloride)</a>产品描述:SKF-96365 hydrochloride, an <b>SOCE</b> inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells.

<i><b>In Vitro:</b></i> SKF-96365 exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells. SKF-96365 inhibits hERG current in a concentration-dependent manner<sup>[1]</sup>. SKF-96365 can induces cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 treatment inhibits the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade. Overexpression of CaMKIIγ or AKT abolishes the effects of SKF-96365 on cancer cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects<sup>[2]</sup>.
<i><b>In Vivo:</b></i> SKF-96365 inhibits CRC cell growth <i>in vivo</i>. SKF-96365 treatment results in a de<br><br>
<br>
<span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">公司介绍:MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库,总部位于美国新泽西,分别在瑞典和上海设有欧洲区子公司和亚洲区总代理,营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商, 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域,PI3K、MAPK等近千个细分靶点,超过4000个活性小分子化合物现货,以及GPCR、API、离子通道等超过20种不同类型的化合物库,同时提供从毫克到千克的专业定制合成服务。</span>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接:<a href="http://www.medchemexpress.cn">www.medchemexpress.cn</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://www.cnbio.net/skin/20004/image/lazy.gif" class="lazy" original="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

alt="">Purity:98%<BR>MWt:434.5771<BR>Formula:C25H34N6O<BR>SMILES:O=C(C1CCC1)NCCCNC2=NC(NC3=CC4=C(CN(C)CC4)C=C3)=NC=C2C5CC5<BR>Pathway:Autophagy; <BR>Mechanisms:ULK; <BR>Research Area:Cancer<BR>电话: 021-58955995<BR>网址: www.MedChemExpress.cn <BR>地址: 上海市浦东新区蔡伦路720号2号楼3层
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