磷脂酰肌醇(植物),(Na +盐) Phosphatidylinositol

磷脂酰肌醇(植物),(Na +盐)  英文名称Phosphatidylinositol, (plant), (Na+ salt) ，货号1048 上海惠诚提供1ml 磷脂酰肌醇(植物),(Na +盐) Phosphatidylinositol, (plant), (Na+ salt)，美国Matreya原装进口

Application Notes:

The metabolism of inositol lipids is involved in the signal transduction of many hormones, neurotransmitters and growth factors.1,2,3 In the classical pathway, phosphatidylinositol-specific phospholipase C (PI-PLC) hydrolyzes phosphatidyl 4,5- bisphosphate (PIP2) to yield 1,2-diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3). The role of IP3 and DAG as second messengers is well recognized. In a second, more recently discovered pathway, the activation of phosphoinositide 3- kinase results in the formation of three novel phosphatidyl (PI) lipids phosphorylated at the D3 positions of the inositol ring: PI-3-P, PI-3,4-P2, and PI-3,4,5-P3. These D3 lipids are not known substrates for any of the phospholipase C enzymes and function as second messengers. PI 3-kinase activity is correlated with many cellular processes including the regulation of cell growth, oncogenic transformation, chemotaxis and receptor down-regulation. A recent paper on the effect of PI-3,4-P2 on the Akt proto-oncogene product also contains protocols for applying PIP’s to cell cultures.4 Matreya’s synthetic phosphatidylinositols and inositol phosphates are excellent tools for investigating these second messengers, understanding the enzyme mechanisms involved in phosphoinositide metabolism and designing therapeutic pharmacological agents.

References: 
1. Bruce A. Fenderson, E. M. Eddy, Sen-Itiroh Hakomori, BioEssays Vol. 12 pp. 173, 1990 
2. P.W. Majerus, Annual Review of Biochemistry Vol. 61 pp. 225-250, 1992 
3. Ao-Lin Hsu, et al., Journal of Biological Chemistry May, Vol. 275 pp. 16242-16250, 2000 
4. H. Shimamura, et al., Journal of American Society of Nephrology Vol. 14 pp. 1427-1434, 2003